Pruning red-hair enchanter's nightshade encourages vigorous growth and helps maintain its desired shape. This process can lead to a more aesthetically pleasing appearance, ensuring red-hair enchanter's nightshade remains an attractive part of the garden landscape.

Pruning or trimming red-hair enchanter's nightshade during late spring and early summer is ideal because it aligns with the plant's post-flowering period. In this phase, red-hair enchanter's nightshade has typically completed its blooming cycle, allowing for the removal of spent flowers and any undesirable or excess growth without negatively impacting the plant's health or next year’s bloom. Pruning in these seasons also takes advantage of red-hair enchanter's nightshade's active growth phase, which means the plant is more resilient and can recover faster from pruning stress. Moreover, performing maintenance before the height of summer helps to mitigate the risk of disease and pest infestation, as wounds can heal more promptly in the mild weather. This timing ensures that the plant maintains an attractive form, encourages stronger growth, and prepares red-hair enchanter's nightshade for the upcoming dormancy in winter.