Pruning potato vine stimulates vigorous new growth, ensuring the plant remains lush and healthy. Keeping potato vine pruned also maintains its shape, enhances its ornamental appeal, and prevents overgrowth that can lead to a disheveled appearance.

Pruning or trimming potato vine during late winter or early spring is optimal since these seasons precede the plant’s active growth period, which typically begins in spring. Trimming in late winter allows removal of any cold-damaged vines before the onset of new growth, ensuring the plant's energy is directed towards producing healthy new shoots. Early spring pruning further stimulates potato vine to produce vigorous growth and abundant flowering throughout the season. These seasons also present an opportunity to shape the plant and manage its size without impacting the forthcoming blossoms, as potato vine tends to bloom on the current year’s growth. It is essential to perform pruning before the plant breaks dormancy to avoid cutting back buds that will produce flowers and potentially fruit. By doing so, the gardener maximizes the health and aesthetic appeal of potato vine, while also maintaining a manageable size and form for the growing season.