White mouth dayflower is native to the Americas and Africa, where it grows in a variety of habitats ranging from forests to sand dunes to roadsides. It has been introduced to Spain and Japan. It has been grown as an ornamental garden plant in its native range and in parts of Europe. White mouth dayflower is not listed as invasive but can become weedy in agricultural contexts.

White mouth dayflower has a wide native range, and has also been listed as endangered in some regions but is not threatened globally. It is planted as an ornamental or groundcover. It is not listed as invasive within the United States, but can be a weed in some agricultural contexts. White mouth dayflower spreads quickly through root shoots in addition to producing seed. In agricultural fields, soil and foliar herbicides have been effective in controlling white mouth dayflower, but it has been shown to be resistant to some herbicides, such as glyphosate. Control methods that do not disrupt roots may not be efficient means of control as it can resprout from rhizomes, but grazing has been shown to offer partial control.

The optimal season to remove the white mouth dayflower plant is in late spring, before the plant blooms and starts producing seeds. Here are a few methods for removing or controlling this plant: