Eastern false rue anemone is a mildly toxic plant. Contact can cause skin irritation, ingestion leads to vomiting, nausea, diarrhea, and possible dehydration. Symptoms include itchy skin, slight swelling, and painful blisters in severe cases. Repeated contact or consumption can exacerbate effects.

While eastern false rue anemone isn't classified as an invasive species, it is a plant of some concern, since all parts of the plant are considered to be mildly toxic to humans. Despite the fact that it is a perennial plant that grows in clusters spreading via tuberous roots, there is no evidence that it grows aggressively to the exclusion of other plants. In fact, the reason eastern false rue anemone might be mistakenly considered this to be a weed is simply the fact that it is so widespread - occurring abundantly in woodlands all across the Eastern United States and Canada. But bear in mind this successful growth is not at the expense of other plant.