Climbing false buckwheat is native to the temperate regions of Eastern Asia. It has been introduced and is now naturalized in various other temperate zones across the globe. The vine is quite adaptable and can thrive in a range of environments, having expanded its presence beyond its native ecosystem.

Climbing false buckwheat is native to the eastern United States. It is planted as an ornamental, attracts pollinators, and provides shelter and nutrition for wildlife. However, it is considered a weed in some contexts and it is banned in Connecticut. It can form dense thickets and sprawl over native vegetation, smothering them. It propagates through self-seeding, producing seeds that are spread easily by the wind. Climbing false buckwheat readily establishes in disturbed areas, including along waterways, roadsides, and anthropogenically disturbed areas. Regular mowing and cultivation are effective methods for controlling weedy populations of climbing false buckwheat.

The best season to remove climbing false buckwheat is springtime, preferably between March and May. It's crucial to remove the plant before it reaches its flowering stage, as this is when it starts to proliferate at a high rate.