Life plant presents a widespread distribution, natively flourishing in major regions of the Southeastern African and Malay Archipelagos. Cultivation of life plant extends beyond its native zones, thriving in various environments across multiple continents, including parts of Asia, Africa, Oceania, and South and Central America. While life plant enriches horticulture collections worldwide, its presence is sometimes thought to be problematic in certain areas. In some regions such as the highlands of South America and the Caribbean, life plant may have an impact on local ecosystems, although it is cultivated elsewhere without significant ecological disruption.

Life plant poses mild toxicity to cats and dogs. Poisoning occurs when pets consume any part of the plant, causing gastrointestinal upset and behavioral changes in cats, and vomiting, diarrhea, and lethargy in dogs. Owners should monitor pets closely and seek immediate veterinary care if ingestion occurs for both species.