The henbit deadnettle is native to temperate parts of Europe and Asia, and ranges as far south as Ethiopia. It grows in disturbed sites as well as in agricultural fields. The species has been introduced to much of Europe, Asia, North Africa, South America, and North America. In several European countries as well as in Australia and many US states, henbit deadnettle is considered an invasive species or troublesome agricultural weed. It is also considered a noxious weed in parts of Canada.

A common weed native to Eurasia and northern Africa, henbit deadnettle has become pervasive around the world. The USA, Western Europe, and Australia all have it listed as an invasive species, and Canada categorizes it as noxious. Henbit deadnettle produces up to 200 seeds per plant, making it an aggressive spreader. It is particularly competitive with crop plants, including winter cereal crops and ornamental landscapes. Henbit deadnettle is also a host to a range of pests that threaten various species of crops, including tomatoes and strawberries, making it a terror for croplands and food gardens. It can quickly cover entire fields without issue and is known to host a variety of pests. Though it spreads widely, it is easily removable by hand.

The best season to remove henbit deadnettle is spring. This is the best time because henbit deadnettle will be in its active growth stage but has not yet produced any seeds. It's crucial to remove it before it reaches its flowering and seed-setting stage to prevent further proliferation.