Hairy white-top is often controlled with herbicides, but just one application is usually not effective at controlling the spread. Chemical control is also more challenging when the plant has established itself among planted, valuable crops. Certain species of legumes are sensitive to herbicides and cannot be sprayed. There are some species of livestock that will eat hairy white-top, such as sheep and goats, and thus can help prevent and control its spread. Preventive measures like checking clothes, shoes, and vehicles after going through a field where hairy white-top is present can also help to reduce its spread.
If you opt for herbicide use, consult an agricultural expert to find the best compound and application method for your geographical region. Read the instructions on the product label and follow them carefully. Spray on a windless day to avoid drift.