Native to a wide range of regions including the Mediterranean, parts of Asia, and extending to the Himalayas, annual yellow sweet clover has been introduced to various other continents such as the Americas, Africa, and Oceania. This plant has adapted to a multitude of climates, spreading beyond its original range to inhabit significant portions of the subtropics and temperate zones around the globe.

Annual yellow sweet clover is toxic to cats and dogs when ingested. Ingestion of any part of the plant can cause gastrointestinal upset and severe symptoms like lethargy and difficulty breathing. Immediate veterinary care is essential if ingestion is suspected.

Annual yellow sweet clover is originally from the Mediterranean region. Despite its sweet-scented yellow flowers and its value as a honey plant, it is considered a weed. The reason lies in its rapid growth rate and capacity for extensive reproduction. It grows quickly and effortlessly in a broad spectrum of environments, including disturbed soils, roadsides, and cultivated fields, which allows it to effortlessly establish itself. As a result, it can become invasive, overtaking native plants and crops in a garden. This competition for resources, such as sunlight, water, and nutrients, can stunt the growth of desired plants, causing irreversible damage. Its most potent weapon, however, is its prolific seed production. Annual yellow sweet clover spreads mainly through its ability to produce a substantial number of seeds, which can be carried by wind, water, animals, or even attached to agriculture equipment, facilitating widespread dispersal and colonization of new areas.

The best time to remove annual yellow sweet clover is in spring or early summer when plants are still young and have not set seed. It is important to remove the plant before it reaches its flowering stage.