Climbing hempvine is a plant primarily native to parts of North America and the Caribbean. Over time, it has been introduced to various regions across Central Africa and South Asia. Its establishment in non-native areas highlights its adaptability and potential as an invasive species, successfully inhabiting multiple continents beyond its original range.

While climbing hempvine is not typically considered to be a weed in its native range (North America), it can become invasive or weedy in regions where it has been introduced. This includes counties in Asia and Oceania as well as the state of Hawaii, which is outside its native range. It can sprawl over and shade native vegetation. Furthermore, it grows rapidly, releases toxins into the soils, and can reproduce both vegetatively and sexually. Avoiding disturbance along waterways can prevent the spread of climbing hempvine. Grazing and applying herbicides can be used to manage unwanted populations of climbing hempvine, while methods that don't remove the roots are unlikely to be effective.

The best season to remove climbing hempvine is early spring before it starts to produce flowers and seeds. Here are some methods for climbing hempvine control: