Large gray willow thrives primarily in the temperate zones of Western Europe and the Mediterranean region. This species has also been introduced to and is now established in the temperate areas of the Southern Hemisphere.

Large gray willow is a small tree that readily invades poor soils. Its suckering roots, quick-growing seeds and dense thickets have made large gray willow invasive in New Zealand and southeast Australia.

The best way to remove large gray willow is before it produces fruits, in order to prevent its further spread. Young plants can be uprooted manually, while removal of mature plants requires a bit more work. Due to its suckering ability and great regenerative potential, cutting large gray willow down isn't a permanent solution. Herbicides need to be applied to the stump so that resprouting is prevented. After the plant has died off, remove as much of the root as possible to make place for other plants. Before picking the herbicide, consult an agricultural expert to find the best active substance for your geographic region. Spray on a windless day to avoid drift.