Cretan bryony is toxic to humans, dogs, and cats. The plant contains cucurbitacins, causing severe gastrointestinal disturbances when ingested. Symptoms include intense abdominal pain, vomiting, diarrhea, and rapid, weak pulse. Both pets and humans need immediate medical attention if exposed to cretan bryony. All parts of the plant are hazardous, affecting the gastrointestinal system and potentially causing severe health issues.