Spotted spurge is a plant with a native range in the subtropical regions of North America. It has since become widely naturalized, spreading to various continents including Europe, Asia, Africa, South America, and Oceania. 'spotted spurge' thrives in diverse climates, establishing itself in major regions across these continents.

Poisoning from spotted spurge affects dogs, cats, and people through ingestion or skin contact, causing nausea, vomiting, diarrhea, and dermatitis. Immediate veterinary care is crucial for pets. Spotted spurge can be found in various environments such as sidewalks, roadsides, gardens, and woodlands.

Spotted spurge grows as a weed in eastern North America, the western United States, and south to Mexico. It is usually considered a weed in gardens and agricultural areas and grows in woods, pastures, lawns, and sidewalk cracks. This species does not appear on any state or national invasive species lists, but it is considered a troublesome crop weed in most southern states. Spotted spurge can overgrow and smother desirable plants and secretes a milky sap that is a skin irritant to people and highly toxic to sheep. Prevent garden germination by mulching, hand pulling plants (preferably before they produce seed), or using of a pre-emergence herbicide.

The best season for the removal of spotted spurge is during the spring or summer. It's crucial to remove this weed before it reaches maturity and begins producing seeds. Here are five organic or possibly interesting methods for weed control: