Eyebane is native to parts of Central and South America. It has since spread to assorted regions across Europe, Asia, North Africa, and Oceania. The plant thrives in various climates and has been introduced to the Mediterranean area, along with temperate and tropical locales on multiple continents.

Eyebane poses a moderate toxicity risk to humans, cats, and dogs due to diterpene esters in its sap. Contact with or ingestion of the sap can cause skin irritation, gastrointestinal issues, and more severe symptoms. Immediate medical or veterinary care is advised if exposure occurs.

Eyebane originates from North America. Known as a weed, it is infamous for its invasive nature, particularly in agronomic crops and gardens. This weed possesses the capacity to reproduce rapidly and grow abundantly, making it a threat to other plants. It can produce up to 3,000 seeds per plant, which significantly contributes to its invasive trait. Eyebane can cause harm by depleting soil nutrients that are necessary for other plants, hampering their growth and threatening biodiversity. This plant predominantly spreads through its prolific seed production, where the seeds are dispersed by wind, water, or through human activities such as gardening and farming. Eyebane can also resprout from broken taproots, making it difficult to control and eradicate. The plant's aggressive growth and adaptability to various conditions underscore its weedy nature.

The best season for the removal of eyebane is during the early summer or late spring. The weed should ideally be removed before it has fully flowered, as this is when it tends to spread seeds. Here are a few methods for controlling or removing this weed: