Tree tobacco, a perennial plant known for its vigorous growth, is intrinsically linked to various regions within South America where it is indigenous. The plant has since broadened its presence, having been introduced to multiple continents, including Europe, Africa, Asia, and North America. During its expansion, tree tobacco has been cultivated, though information on the extent of its cultivation remains limited. In some areas beyond its native range, tree tobacco is sometimes thought to be invasive, potentially influencing local ecosystems where it competes with native flora. However, the full impact on these ecosystems is not always explicitly documented.

Tree tobacco is the most dangerous plant in the tobacco family due to its toxins, particularly nicotine and anabasine. Consumption of any part can cause severe symptoms like nausea, vomiting, rapid heart rate, paralysis, and death in both humans and pets, including cats and dogs. Immediate medical attention is required for exposure or ingestion. Keep away from vulnerable individuals and animals.