Shrubby jerusalem sage is indigenous to the Mediterranean region, thriving in its maquis and garigue habitats. Over time, shrubby jerusalem sage has been introduced and cultivated in temperate parts of Eurasia, which has led to a presence primarily across the Mediterranean basin and extending into parts of Eurasia. Its adaptability allows it to flourish in various settings beyond its original range.

Shrubby jerusalem sage hails from the eastern Mediterranean region, an environment that affords it traits beneficial for both garden growth and invasive tendencies. It's considered a weed due to its assertive self-seeding capability, spreading prolifically and dominating the garden it inhabits. Furthermore, its deep root system can make it a difficult weed to eradicate. This system not only provides the plant with resilience but can potentially interrupt the balance of your garden ecosystem by outcompeting and overshadowing other plant species. If you have chosen to cultivate shrubby jerusalem sage in your garden, it's critical to frequently monitor its growth, looking out for excessive spreading. Moreover, shrubby jerusalem sage's primary propagation method is through its seeds, making successful containment a task of diligent removal of its flowering heads before they go to seed.

To best manage shrubby jerusalem sage, removal or control efforts should take place in the late winter or early spring before the plant sets seed. Control is most effective at this stage to prevent spreading.