The geographical presence of sicklepod spans across various continents where it is native to parts of South and Central America, as well as the Middle East. It has also been introduced to regions in Africa, Asia, and Europe, where its presence is notable but not dominant. Sicklepod has become naturalized in some of these areas, and in certain places, it is sometimes thought to be invasive, potentially posing an impact on local ecosystems. The extent of its impact, however, varies and is not uniformly observed across its introduced range.

Sicklepod poses mild toxicity to humans, cats, and dogs. The plant contains anthraquinones, glycosides, and lectin, causing symptoms like nausea, vomiting, diarrhea, tremors, and weakness upon ingestion. In severe cases, it can lead to heart damage or failure and damage to muscles, liver, kidneys, and lungs. Immediate veterinary care is essential for pet poisoning.

Sicklepod hails from tropical and subtropical regions, especially America. It is considered a weed due to its notorious ability to proliferate, spread, and cause harm, especially in agricultural landscapes. Sicklepod's hardiness and rapid reproductive capabilities make it a formidable weed, capable of usurping nutrients, sunlight, and other resources, thereby hindering crop growth. It is also resistant to certain herbicides, making it difficult to control. Its flexible survivability, coupled with its potential to produce huge numbers of seeds that can remain dormant in the soil for years, exacerbates the threat. Furthermore, sicklepod can indirectly harm other plants by attracting pests that could spread diseases to crops. The main mode of spread is through its seeds, which can be transported by wind, water, or by sticking to animals and humans.

The best season for removal of sicklepod is during the early spring or late winter season, as the plant is still young and easier to manage. You should remove sicklepod before it reaches the flowering stage to prevent it from spreading any seeds.