Tuberous comfrey is mildly toxic to humans, cats, and dogs. All parts contain alkaloids causing nausea, vomiting, dizziness, and headaches. Cats and dogs may exhibit gastrointestinal upset, drooling, vomiting, or diarrhea upon ingestion. Immediate veterinary care is essential if tuberous comfrey poisoning is suspected to ensure effective treatment and prevent further health complications. Caution is advised to avoid accidental ingestion.