Despite its desirable aromatic properties, common mugwort can be a very weedy plant. It is undesirable in agricultural fields, along railways and roadsides. It is also listed as a common or troublesome agricultural weed in the US states of North Carolina, South Carolina, and Georgia.
Common mugwort is difficult to control because it spreads efficiently underground via rhizomes, plus it is a generally hardy plant. These traits make it capable of taking over large areas if not controlled. Another reason it is considered a weed is that it causes dermatological toxicity in some susceptible individuals. In warmer regions, it can also spread via seeds.
Controlling common mugwort manually can be a time-consuming task, but it is still doable. Removing the plants constantly by hand or machine will eventually exhaust the entire plant, including the underground stems.