Wandering Jew is native to tropical and subtropical regions of Africa and Asia. It has been introduced and become naturalized in the Americas, spanning diverse environments. Wandering Jew thrives in a wide range of habitats which has led to its extensive spread across continents but also raising concerns as an invasive species in some regions.

Wandering Jew originally hails from tropical and subtropical Asia, and is now common worldwide. Known as invasive, this plant is considered a weed due to its prolific ability to reproduce and spread. Each plant produces an impressive number of seeds that disperse, grow quickly, and become nearly impossible to fully eradicate. Elevated harmfulness to gardens arises from its relentless spread, rapidly invading and pushing out beneficial plants. Furthermore, with the unique ability to grow from fragments, dropped or carried away by animals, garden tools, or water, the weed can regenerate and continue to flourish. Wandering Jew's main propagation method is the combination of seeds and vegetative reproduction through its segmented stems. Mixed clusters of seeds and stem fragments can inadvertently spread through contaminated soil, garden waste, or even on footwear, contributing to its persistence in new environments.

The best season to remove 'wandering Jew' is late spring or early autumn. The weed should be removed before it has the chance to seed in order to prevent further dispersal and growth.