Flaxleaf fleabane is native to the tropical and subtropical regions of the Americas and parts of Asia. It has been introduced to numerous other regions, establishing itself across multiple continents including Africa, Europe, and Oceania. Far-reaching from its origins, flaxleaf fleabane has acclimatized to a variety of climates and is found in a range of non-native ecosystems.

Flaxleaf fleabane causes dermatitis upon skin contact, hay fever symptoms upon inhalation, and is toxic to cats and dogs upon ingestion, particularly the leaves. Symptoms in pets include vomiting, diarrhea, and lethargy. Immediate veterinary care is crucial if poisoning is suspected. Use protective gear when handling flaxleaf fleabane to prevent skin irritation. Avoid exposing pets to this plant. Be vigilant for ingestion signs.

Flaxleaf fleabane is native to Central and South America but has since spread to North America, Europe, Africa, Asia, and Australia. This plant occupies numerous habitats, including driveways, parks, wetlands, disturbed areas, and orchards. In orchards, it is particularly problematic because it invades commercial crops. Flaxleaf fleabane is considered invasive in over seventy-seven countries, including Belgium, Italy, Ecuador, Spain, and South Africa. In Brazil, it is a known host for the lettuce mosaic virus, which negatively affects commercial lettuce yields. When necessary, flaxleaf fleabane can be controlled through the use of chemical herbicides such as glyphosate. Alternatively, tilling the soil may discourage the growth of seedlings.

The best season for the removal of flaxleaf fleabane is during late winter or early spring, before the plant has a chance to flower and set seeds. This helps to prevent new generations of the plant from spreading.