Prostrate sandmat can cause contact dermatitis with its milky latex, leading to redness, swelling, and blisters on skin exposed to sunlight. All parts are toxic and ingestion can cause nausea, vomiting, and diarrhea in humans. Dogs and cats can be mildly poisoned through ingestion, showing symptoms like vomiting, diarrhea, and lethargy. Prompt veterinary care is advised for pets.