German chamomile is native to Eurasia and into the north of Africa. It has been introduced widely into North America, parts of South America, parts of Africa and Australia. It is also widely cultivated. It is easy to grow anywhere, requiring only some sunlight and reasonably rich topsoil.

German chamomile poses mild toxicity risks to dogs and cats. Ingestion of any part can cause poisoning, leading to symptoms like gastrointestinal upset and skin irritation. It can cause mild allergic reactions in sensitive humans, with symptoms like an itchy rash. Avoid consumption or topical use before surgery or if sensitive to estrogen. Immediate veterinary care is crucial for pets. Secure treatment if poisoning is suspected.

Native to Eurasia, german chamomile has been spread to most temperate areas around the world. In the United States, it is naturalized throughout the northwest, upper midwest, and northeast and is listed as invasive or noxious in Alaska, Washington, and Colorado. It is cultivated extensively for its many uses, however it frequently escapes cultivation. Individual plants can produce up to 300,000 seeds that are spread readily by water, animals, and agricultural activities. Plowing and mechanical weeding have been effective in controlling german chamomile as an agricultural weed. Sowing competitive forage species and herbicide application may also be effective, although german chamomile is resistant to certain herbicides.

The best time to manage german chamomile is in late winter or early spring before it starts to flower. Control should occur before the plants set seed to prevent further spread.