Clammy ground cherry is native to North America and has become introduced to parts of Europe. Its presence spans a significant variety of habitats within these major regions, showcasing its adaptability to diverse environmental conditions.

Clammy ground cherry is extremely toxic to humans, especially its fruit and leaves. It contains solanine, causing headaches, vomiting, diarrhea, abdominal pain, and disrupted systems. Ingesting large amounts can be fatal.

Clammy ground cherry is native to Canada and the United States. The weed can be found in woods, thickets, and waste areas in USDA zones 7 to 10. It has been recorded as an invasive weed in Japan, India, and Croatia. In Japan, clammy ground cherry competes with native species for nutrition, interferes with crop growth, and hosts viruses that may negatively impact commercial crops. Furthermore, it is considered poisonous to cattle and other mammals due to its high amounts of solanum. Clammy ground cherry can be controlled by the mechanical removal of young plants before they form deep root systems, or alternatively with chemical treatments of glyphosate.

For clammy ground cherry, it's best to remove this plant during the early summer season, before the plant reaches its fruit-bearing state, usually around late June to mid-July.