Poisoning from buffalo bur is likely from accidental ingestion, with all parts highly toxic and potentially deadly. Symptoms include nausea, vomiting, diarrhea, stomach cramps, burning throat, headache, dizziness, and severe cases may lead to hallucinations, paralysis, and death. For cats and dogs, ingestion causes vomiting, diarrhea, and lethargy, requiring immediate veterinary care to prevent severe reactions.