Redroot amaranth is considered a weed throughout the eastern United States and Canada. In the United States, it is a weed from Texas to North Carolina. In total, it is considered an invasive weed in 58 countries such as France, Belgium, Russia, Germany, and Portugal. The plant prefers to root in disturbed non-wetland areas. This species hosts pests that damage important crops such as maize, cotton, and sorghum. The redroot amaranth is highly poisonous to grazing animals and humans due to the nitrates that it pulls up from the soil. It can be controlled through herbicides, cultivation, or by introducing beetles such as the pigweed flea beetle.