All parts of stinking hellebore are moderately toxic. Ingesting stinking hellebore can induce symptoms like burning sensation, vomiting, diarrhea, and depression in humans, dogs, and cats. The toxins can have adverse interactions with certain medications. Immediate veterinary care is crucial if pets ingest stinking hellebore to minimize health risks. Stinking hellebore may cause discomfort and illness in cats upon contact. Seek vet care promptly in suspected poisoning cases. For humans, the plant's toxins exacerbate the effects when combined with beta-blockers, steroids, or chemotherapy drugs.