Water lettuce is widely distributed across tropical and subtropical regions on several continents. Native to parts of Africa, Asia, and South and Central America, its presence is established through a combination of natural prevalence and human cultivation. Water lettuce has been introduced to Europe, Asia, and the island nations, where it has adapted to various environments. Although it is cultivated, in certain areas water lettuce is sometimes thought to be invasive, potentially affecting ecosystems by altering habitats and competing with local flora. However, its actual impact can vary widely, and it is not universally regarded as a disruptive species.

Water lettuce contains calcium oxalate, causing mild toxicity to humans, cats, and dogs. Symptoms of ingestion include mouth irritation, difficulty swallowing, vomiting, and diarrhea. Immediate veterinary care is crucial for pets to manage these reactions effectively and improve their prognosis. Avoid accidental ingestion to prevent adverse health effects in humans and animals. All parts of water lettuce are toxic.}

Water lettuce(Pistia stratiotes) is most commonly grown as an ornamental plant, particularly in Europe, to be used in ponds and aquariums. However, it has been reported as being invasive in warmer parts of the United States, such as Florida.

The best season to manage water lettuce is during late spring or early summer, before it has a chance to heavily reproduce. It's crucial to restrict or control water lettuce before it reaches its flowering stage to prevent it from spreading too much.