Pigeonberry originates from the tropical and subtropical Americas, spanning several major regions across two continents. Its growth has taken root extensively in these native lands. Beyond its place of origin, pigeonberry has spread to areas across Africa, Asia, the Pacific Islands, and Southern Europe. Though not originally from these regions, pigeonberry has established its presence gently in some areas, and is sometimes thought to be a mild concern in certain ecosystems, particularly in parts of the Asia-Pacific region, where it may have an impact on local flora.

All parts of pigeonberry are toxic when ingested, especially berries, roots, and leaves. Humans, cats, and dogs must avoid consumption. Symptoms in humans include numbness, warmth, fatigue, thirst, vomiting, and diarrhea. For cats and dogs, ingesting pigeonberry can cause gastrointestinal upset and more severe signs. Immediate veterinary care is crucial for pets showing symptoms of poisoning. Avoid letting pets access pigeonberry.

Pigeonberry is native to the Americas and has been planted as an ornamental and for dyeing purposes. It has been introduced throughout much of the rest of the world and has been reported as invasive in 26 countries and islands. Pigeonberry grows rapidly and is shade tolerant, which allows it to outcompete native species. It is a habitat generalist, which allows it to grow within agricultural contexts, forests, roadsides, and urban areas. It produces abundant fruits, which allows for wide and rapid distribution via birds. Additionally, parts of the plant are toxic to humans. Herbicide can be effective in controlling unwanted populations of pigeonberry.

For 'pigeonberry', the most effective time for weed control is late spring or early summer when the plant is in its active growth phase but before it flowers and sets seeds.