Wild cosmos is native to parts of Central and South America, thriving in various ecosystems without notable disruption. In cultivation, wild cosmos is favored in numerous regions, extending its presence into Southeast Asia and the Pacific, where it is appreciated for various attributes. While wild cosmos has been introduced to a broad range of locales globally, it is sometimes thought to be naturalized in parts of Asia and the Caribbean, where it may have an impact on local ecosystems. Wild cosmos reflects a plant that has adapted to different environments, both as a native species and in cultivation, with careful management when necessary.

Wild cosmos is mildly toxic to humans. Consumption of any part can cause nausea, vomiting, diarrhea, burning sensation in the mouth, and swelling of lips, tongue, and throat, leading to difficulty swallowing. Care should be taken to avoid ingestion, as the plant may be mistaken for an edible species.